The Digest’s 2023 Multi-Slide Guide to the Agile BioFoundry Projects

September 07, 2023

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by Jim Lane (Biofuels Digest) The Agile BioFoundry is a consortium of seven U.S. Department of Energy (DOE) national laboratories that operate as a distributed biofoundry in collaboration with industry and academia. They partner with the biomanufacturing industry to accelerate bioproduct development. Advancing biomanufacturing across the public and private sectors. Here, BETO Conversion Technology Manager Gayle Bentley gave this overview of DOE’s goals with the ABF, at DOE’s Project Peer Review meetings. READ MORE

DOE and NSF Select Three Projects to Accelerate Biomanufacturing Innovation and Advance the U.S. Bioeconomy (Bergeson & Campbell)

Accelerating Innovations in Biomanufacturing Approaches through Collaboration Between NSF and the DOE BETO funded Agile BioFoundry (NSF-DOE/ABF Collaboration) 2023 ABF NSF-DOE Awards Announcement (National Science Foundation)

Excerpt from National Science Foundation: Biotechnology and biomanufacturing continue to offer vast opportunities to advance science and engineering, support a growing U.S. bioeconomy, and provide solutions to our nation’s climate change challenges. To help accelerate innovation and develop new biomanufacturing approaches, three new projects were selected for funding from the U.S. Department of Energy (DOE) Bioenergy Technologies Office (BETO) and the U.S. National Science Foundation (NSF).

Through the funding opportunity titled, “Accelerating Innovations in Biomanufacturing Approaches through Collaboration Between NSF and the DOE BETO-funded Agile BioFoundry (ABF), researchers will collaborate with the ABF consortium’s synthetic and bioengineering research projects. “The U.S. has set aggressive decarbonization goals for 2030 and beyond,” said Dr. Valerie Sarisky-Reed, BETO Director. “These award recipients will leverage ABF’s rapid prototyping and advanced biotechnology resources to accelerate basic research projects to deployment, reducing America’s dependence on fossil fuels and lowering greenhouse gas emissions from fuel and chemical production.”

BETO and NSF have selected the following projects:

The University of California, Irvine and University of California, Davis will jointly work to enhance the carbon and energy efficiency of a biomanufacturing process by upgrading carboxylic acids into precursors for biofuels and chemicals used in industry.

Researchers at the University of Wisconsin–Madison will develop and use tools to close knowledge gaps surrounding transporters in Gram-negative bacteria to facilitate the development of superior biomanufacturing hosts.

University of Georgia researchers will work to increase understanding of the metabolic pathways that allow the microorganism Megasphaera elsdenii to produce hexanoic acid, that can be engineered to create sustainable aviation fuel among a host of other products.

Funded by BETO, ABF aims to develop biomanufacturing tools, processes, and partnerships that enable sustainable industrial production of renewable fuels and chemicals for the nation. The integrated Design-Build-Test-Learn capabilities of the ABF offer a unique resource to the academic community to develop and implement innovative biomanufacturing technologies and practices.

“The NSF and BETO both recognize the critical roles that synthetic and engineering biology play in advancing the U.S. bioeconomy,” said Dr. Susan Marqusee, assistant director for biological sciences at NSF. “The selected projects all directly contribute to the production of renewable biochemicals and biofuels and build foundational technologies critical for limiting the carbon footprint of industry.”

All selected projects address goals from the recent White House Office of Science and Technology Policy report Bold Goals for U.S. Biotechnology and Biomanufacturing, to which both NSF and DOE contributed. The report outlines ambitious national targets for the next two decades to help establish R&D priorities that will be critical to advance the bioeconomy.

ABF partners include Argonne National Laboratory, Lawrence Berkeley National Laboratory, Los Alamos National Laboratory, the National Renewable Energy Laboratory, Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Sandia National Laboratories, and more than 30 university and industry partners.