by Jim Lane (Biofuels Digest) The company manufactures custom, high-quality, synthetic DNA used by scientists to construct genes, pathways, genomes and organisms that will enable the next generation of breakthroughs in biology. Founded by pioneering scientists in fabrication, genetics, and bio-engineering,
synthetic biology
Back TO HOMEReinventing Enzymes, Molecules by Design: The Digest’s 2016 Multi-Slide Guide to Arzeda
by Jim Lane (Biofuels Digest) Arzeda’s proprietary technology combines targeted computational enzyme design and protein optimization with state-of-the-art metabolic bioengineering to create entirely novel designer cell factories capable of industry-scale chemical production. CEO Alex Zanghellini gave this overview of Arzeda’s breakthrough technology at ABLC Next in San
November 14, 2016 Read Full Article
The Digest’s 2016 Multi-Slide Guide to Innovation in Agtech, Foodtech, and Renewable Chemicals
by Jim Lane (Biofuels Digest) What are the true drivers of Innovation in Agtech, Foodtech, and Renewable Chemicals? AT ABLC Next in San Francisco, the opening plenary session looking at this topic featured Roger Wyse, managing partner of Spruce Capital Partners,
November 08, 2016 Read Full Article
Strategic Intent: The Digest’s 2016 Multi-Slide Guide to BASF, Audi
by Jim Lane (Biofuels Digest) This season, The Digest is hosting the Strategic Intent webinar series, looking at the plans, progress and future milestones of strategic stakeholders in the Advanced Bioeconomy. In this slide deck, we looked at BASF and Audi and their direct investments,
October 12, 2016 Read Full Article
Biorenewables Megatrends: The Digest’s 2016 Multi-Slide Guide to the Advanced Bioeconomy’s Progress
by Jim Lane (Biofuels Digest) This week, we conducted a webinar on Biorenewables Megatrends with NEXANT principal Ron Cascone, who gave these incisive slides on the state of commercialization in fuels, chemicals, biomaterials and nutrition. READ MORE and MORE (Singularity Hub)
August 26, 2016 Read Full Article
Sustainable and Low-Cost: The Digest’s 2016 Multi-Slide Guide to Competing with Sub-$50 oil
by Jim Lane (Biofuels Digest) As Irshad Ahmed observed recently in The Digest, “until such time that we internalize the true life-cycle costs of extracting and using fossil fuels, and distinguishing fossil-BTUs from bio-BUTs, we will continue to struggle to find
August 02, 2016 Read Full Article
Big Data, Robotics and Synth Bio: Driving “The New Agriculture”
by Jim Lane (Biofuels Digest) ... If you haven’t been to an LP meeting before, they are generally intimate gatherings of venture capitalists, their underlying investors (the Limited Partners), portfolio company CEOs, and some thought leaders invited to share their perspective
June 22, 2016 Read Full Article
Of Sausage-Making, DC and Bioenergy Budgets
by Jim Lane (Biofuels Digest) The signals coming out of Washington DC are so confusing, you might be wondering if there’s going to be a budget for the US Department of Energy for the fiscal year starting this October. ... Meanwhile, the DOE’s
June 02, 2016 Read Full Article
The SynBio Foundry: The Digest’s 2016 8-Slide Guide
by Jim Lane (Biofuels Digest) Lawrence Berkeley National Lab, Ames National Lab, Argonne National Lab, Idaho National Lab, Los Alamos National Lab, the National Renewable Energy Lab, Oak Ridge National Lab, Pacific Northwest National Lab, and Sandia National Lab seek
May 27, 2016 Read Full Article
Why Does Biology Take so Long to Make Commercial Products? A Job for BOB
by Jim Lane (Biofuels Digest) ... (W)hy is so biology so challenging? -- “It’s partly how we have done it. We sort through the research, then we design, and then we spend a lot of time in the lab pipetting
May 26, 2016 Read Full Article
Renewable Specialty Chemicals: The Digest’s 2016 Multi-Slide Guide to Green Biologics
by Jim Lane (Biofuels Digest) Green Biologics is focused on the production of renewable n-butanol and other C4 chemicals from various renewable feedstocks, including sugar (cane, molasses, beets), starch (corn) and cellulosic biomass (corn residues, sugar cane bagasse, forest materials
May 19, 2016 Read Full Article
Harnessing Biotechnology to Accelerate Advanced Biofuels Production
by Jonathan Male (US Department of Energy) ... From expanding the potential of diverse microbial systems to enhancing the biocatalytic capabilities of enzymes, the application of biotechnology is accelerating the development of the advanced biofuel industry. The U.S. Department of Energy’s Bioenergy
April 12, 2016 Read Full Article
Major Advance in ‘Synthetic Biochemistry’ Holds Promise for Industrial Products and Biofuels
by Stuart Wolpert (University of California - Los Angeles) UCLA biochemists have devised a way to convert sugar into a variety of useful chemical compounds without using cells -- UCLA biochemists have devised a clever way to make a variety of
April 12, 2016 Read Full Article
Drop in, Trip Out, Turn On: The Digest’s 2016 Multi-Slide Guide to Drop-In Fuels
by Jim Lane (Biofuels Digest) Yesterday, we held a well-attended webinar on “Drop-In Fuels” Here below is the first slide deck presented on the day. We’ll have the remainder of slides tomorrow. The recorded version can be accessed here. READ MORE
March 31, 2016 Read Full Article
Biobased Plastics and Resins, What’s New, and Who’s Top Cat?: The Digest’s 2016 Visual Guide
by Jim Lane (Biofuels Digest) Yesterday, we held a well-attended webinar on “Biobased Plastics and resins?” Here below are the slides presented on the day. The recorded version can be accessed here. READ MORE
March 30, 2016 Read Full Article
Designer Enzymes and Strains: The Digest’s 2016 8-Slide Guide to Arzeda
by Jim Lane (Biofuels Digest) 100,000+ naturally occurring molecules are known but the biosynthesis is unknown — and cannot be made economically at any scale, today. Meanwhile, millions of synthetic non-natural molecules that could be made with designed enzymes and
January 22, 2016 Read Full Article
Plug-and Play Synthbio: Arzeda, INVISTA, Others Finding New Pathways to Affordable, Everyday Materials
by Jim Lane (Biofuels Digest) A new generation of advanced technologies, based primarily in the United States but active in Europe and around the world, is changing our way of thinking about what a factory has to look like, one
January 18, 2016 Read Full Article
E Pluribus, Unum: LanzaTech, Global Bioenergies Demonstrate The Biotechnology App Store
by Jim Lane (Biofuels Digest) As Global Bioenergies, LanzaTech tighten isobutene partnership, the era of “swap-in, swap out” biorefining microbes comes clear, closer -- In France, Global Bioenergies and LanzaTech signed a new collaboration agreement to broaden the feedstock flexibility
January 11, 2016 Read Full Article
Innovation to Tackle Climate Change and Feed a Growing Population: Commercializing Synthetic Biology
by Vonnie Estes (Biofuels Digest) ... But as the land, water, and fossil fuel resources those systems rely on become scarcer, biology is offering new ways to engineer solutions. Synthetic biology redesigns existing organisms for specific purposes to produce safe products
December 02, 2015 Read Full Article
Oils that Aint Oils: The Digest’s 2015 8-Slide Guide to Novvi
by Jim Lane (Biofuels Digest) Novvi LLC is a joint venture of Amyris, Inc. and Cosan S.A. Industria e Comercio created to develop, produce, market, and distribute high-performance oils and lubricants from renewable sources. Novvi draws from the strength of both
November 17, 2015 Read Full Article
Seeking Better Biofuels
by Melody M. Bomgardner (Chemical & Engineering News) Researchers at the Joint BioEnergy Institute transform biomass into energy-rich fuel molecules -- .. JBEI researchers are zeroing in on concepts that others have decided are too difficult or would take too
October 26, 2015 Read Full Article
Synthetic Biology Comes in Peace
by Kevin Mayer (Genetic Engineering and Biotechnology News) Scientists Wonder if the Public Is Prepared for Designer Genomes --- Given its current trajectory and rate of approach, synthetic biology is hurtling toward a close encounter with the public. Yes, synthetic biology
August 28, 2015 Read Full Article
Three Recent Developments in Synthetic Biology You Need to Know
By Dominic Basulto (The Washington Post) Using synthetic biology techniques, researchers have created everything from new flavors and fragrances to new types of biofuels and materials. While the innovation potential of combining biology and engineering is unquestionable, now comes the
May 14, 2015 Read Full Article
Thrive, Survive, Jive or Take Five: Who Is Weathering the $50 Oil Storm in Biofuels, and How?
by Jim Lane (Biofuels Digest) ... Survive -- First-Gen ethanol producers. So-so. Corn prices have fallen, and though margins have been compressed and gone negative in some cases, balance sheets remain strong and the margin outlook is improving and positive
May 14, 2015 Read Full Article
The Commercialization of Renewable Fuels, Chemicals and Biobased Product: 4 New Views, in Depth
by Jim Lane (Biofuels Digest) New targets, new markets, new tech, new methods, new outcomes.LanzaTech, Genomatica, Amyris and Brazil’s CTBE share in-depth presentations from the 37th Symposium on Biotechnology for Fuels and Chemicals. 100 of the most fascinating slides you’ll
May 13, 2015 Read Full Article
Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae
(J. Craig Venter Institute) Results have important implications in developing algae-based products such as biofuels and chemicals -- Scientists from the J. Craig Venter Institute (JCVI), a not-for-profit genomic research organization, published a paper today (April 21, 2015) outlining new
April 24, 2015 Read Full Article
US Poised for Biobased Chemicals Breakout, Says National Research Council
by Jim Lane (Biofuels Digest) Though challenges remain, particularly in affordable feedstock, the US National Research Council says “Despite impressive recent and projected growth, the manufacturing of chemicals using biological synthesis and engineering could expand even faster.” ... In Washington, the National
April 06, 2015 Read Full Article
Harvard Researchers Report Bacteria Breakthrough in Mass-Chemical Production
by Jessica Bartlett (Boston Business Journal) A Harvard geneticist may have unlocked the code to large-scale chemical and biofuel production, saying that researchers used the theory of evolution to trick bacteria into mass-making useful chemicals. Reported in the Proceedings of the National
December 30, 2014 Read Full Article
Connecting the Microcosmos and the Macro World
by Glen Martin (O'Reilly Radar) Christina Agapakis explores the microbiological matrix that binds everything from pecorino to people. ... Agapakis is first and foremost a synthetic biologist and a microbiologist, but she’s not particularly happy with the way the synthetic biology narrative
November 05, 2014 Read Full Article
Transforming Toxic Waste into Green Energy
by Christian Durand (Concordia University) Emerging graduate research at Concordia seeks to turn pulp mills into dynamic biorefineries How can a struggling industry like pulp and paper in Canada be revived? According to Damien Biot-Pelletier, a Concordia PhD candidate in biology, the
November 03, 2014 Read Full Article
An Ecological Risk Research Agenda for Synthetic Biology
(Synthetic Biology Project) Environmental scientists and synthetic biologists have for the first time developed a set of key research areas to study the potential ecological impacts of synthetic biology, a field that could push beyond incremental changes to create organisms
June 09, 2014 Read Full Article
Companies Quietly Apply Biofuel Tools to Household Products
by Stephanie Storm (The New York Times) Consumer products containing ingredients made using an advanced form of engineering known as synthetic biology are beginning to show up more often on grocery and department store shelves. A liquid laundry detergent made by
June 02, 2014 Read Full Article
Why the Promise of Cheap Fuel from Super Bugs Fell Short
by Martin LaMonica (MIT Technology Review) The sell-off of synthetic biology pioneer LS9 goes to show that making biofuels from genetically engineered microbes has yet to deliver economically. ... LS9 had hoped to be selling diesel to refineries at least two years
February 06, 2014 Read Full Article
Help, I’ve Fallen and My Enterprise Can’t Get Up: Goldilocks, Right-Sizing and Synth-Bio
by Jim Lane (Biofuels Digest) The story of Pareto Biotechnologies, RuBisCo, the pesky failures of evolution, and help for those who have fallen and can’t get up, via a right-sized approach. Not too high a goal, not too low. Not
December 16, 2013 Read Full Article
Embracing Open-source Biotech: DNA Freeware May Out-Innovate Patented Genes
(Lux Research) Corporations will need to integrate open source with traditional patents for biotech innovations in medicine, renewable materials, and nutrition, Lux Research says With synthetic biology (synbio) rapidly gaining momentum, and a landmark U.S. Supreme Court judgment striking down an
September 03, 2013 Read Full Article
NSF Accepting Grant Applications under BBBE Program
by Erin Voegele (Ethanol Producer Magazine) The National Science Foundation recently opened a new funding opportunity under its Biotechnology, Biochemical, and Biomass Engineering program. According to the grant notice, the program supports fundamental engineering research that advances the understanding of
August 26, 2013 Read Full Article
Exxon at Least 25 Years Away From Making Fuel From Algae
by Joe Carroll (Bloomberg) Exxon Mobil Corp. (XOM)’s $600 million foray into creating motor fuels from algae may not succeed for at least another 25 years because of technical hurdles, said Chairman and Chief Executive Officer Rex Tillerson. So far, scientists
March 08, 2013 Read Full Article
The Dew Drop Inn — Who’s Dropping in What in Biofuels?
by Jim Lane (Biofuels Digest) B20, B5, B100, E10, E22, E15, M50, E85, Bu12.5, HEFA 50. Is your head swimming with acronyms and blend ratios? Who exactly is making drop-in fuels, and what does that mean? In the world of alternative
February 19, 2013 Read Full Article
How Joule May Turn Biofuels Upside Down
by Jim Lane (Biofuels Digest) ...But some of the most interesting work being done today at Joule Unlimited is of the “Don’t Bee” type: progressively knocking out characteristics and pathways that create limitations on biofuels production: “Don’t BEE a naughty
July 20, 2012 Read Full Article
CAD for RNA: Joint BioEnergy Institute Researchers Develop CAD-Type Tools for Engineering RNA Control Systems
by Lynn Yarris (Lawrence Berkeley National Laboratory) The computer assisted design (CAD) tools that made it possible to fabricate integrated circuits with millions of transistors may soon be coming to the biological sciences. Researchers at the U.S. Department of Energy
December 30, 2011 Read Full Article
Friends of the Earth Calls for Moratorium on Synthetic Bio-Based Biofuels
by Jim Lane (Biofuels Digest) In Washington, Friends of the Earth released a report “Synthetic Solutions to the Climate Crisis: The Dangers of Synthetic Biology for Biofuels Production,” concluding that synthetic biology projects including the creation of algae with synthetic
October 04, 2010 Read Full Article
Synthetic Bio Could Cure Energy Woes
by Ph.D. Angelo DePalma (CheckBiotech, Genetic Engineering & Biotechnology News) ...“It is about systems,” says A. Malcolm Campbell, Ph.D., professor of biology at Davidson College, “not manipulating one or two genes, but whole pathways.” For example, producing a compound in